癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
INA Antibody
Mouse Monoclonal Antibody (Mab)
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- 背景知识
Application 
| IF, IHC-P, WB, E |
|---|---|
| Primary Accession | Q16352 |
| Other Accession | P23565, P46660, Q08DH7, NP_116116.1 |
| Reactivity | Human, Mouse |
| Predicted | Rat, Bovine |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1,k |
| Clone Names | 257CT7.1.2 |
| Calculated MW | 55391 Da |
| Antigen Region | 290-319 aa |
| Gene ID | 9118 |
|---|---|
| Other Names | Alpha-internexin, Alpha-Inx, 66 kDa neurofilament protein, NF-66, Neurofilament-66, Neurofilament 5, INA, NEF5 |
| Target/Specificity | This INA antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 290-319 amino acids from human INA. |
| Dilution | IF~~1:10~50 IHC-P~~1:100~500 WB~~ 1:125 E~~Use at an assay dependent concentration. |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | INA Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | INA |
|---|---|
| Synonyms | NEF5 |
| Function | Class-IV neuronal intermediate filament that is able to self- assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NEFL to form the filamentous backbone to which NEFM and NEFH attach to form the cross-bridges. May also cooperate with the neuronal intermediate filament protein PRPH to form filamentous networks (By similarity). |
| Tissue Location | Found predominantly in adult CNS. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene is a member of the intermediate filament family and is involved in the morphogenesis of neurons.
REFERENCES
Leermakers, F.A., et al. Eur. Biophys. J. 39(9):1323-1334(2010)
Martins-de-Souza, D., et al. J Psychiatr Res 43(11):978-986(2009)
Ducray, F., et al. Neurology 72(2):156-161(2009)
Willoughby, V., et al. Appl. Immunohistochem. Mol. Morphol. 16(4):344-348(2008)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
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