癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GJC2 Antibody (N-term)
Mouse Monoclonal Antibody (Mab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q5T442 |
| Other Accession | NP_065168.2 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgM |
| Clone Names | 391CT6.4.3 |
| Calculated MW | 47002 Da |
| Antigen Region | 32-61 aa |
| Gene ID | 57165 |
|---|---|
| Other Names | Gap junction gamma-2 protein, Connexin-466, Cx466, Connexin-47, Cx47, Gap junction alpha-12 protein, GJC2, GJA12 |
| Target/Specificity | This GJC2 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 32-61 amino acids from the N-terminal region of human GJC2. |
| Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GJC2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GJC2 |
|---|---|
| Synonyms | GJA12 |
| Function | One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Cell junction, gap junction |
| Tissue Location | Expressed in central nervous system, in sciatic nerve and sural nerve. Also detected in skeletal muscles |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
GJC2 is a gap junction protein. Gap junction proteins are members of a large family of homologous connexins and comprise 4 transmembrane, 2 extracellular, and 3 cytoplasmic domains. This gene plays a key role in central myelination and is involved in peripheral myelination in humans. Defects in this gene are the cause of autosomal recessive Pelizaeus-Merzbacher-like disease-1.
REFERENCES
Ferrell, R.E., et al. Am. J. Hum. Genet. 86(6):943-948(2010)
Wang, J., et al. Brain Dev. 32(3):236-243(2010)
Ishikawa, T., et al. Rinsho Shinkeigaku 50(1):7-11(2010)
Ruf, N., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (2), 226-232 (2009) :
Orthmann-Murphy, J.L., et al. Brain 132 (PT 2), 426-438 (2009) :
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