癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
HPRT1 Antibody(Ascites)
Mouse Monoclonal Antibody (Mab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P00492 |
| Other Accession | Q6LDD9, NP_000185.1 |
| Reactivity | Human |
| Predicted | Monkey |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgM |
| Clone Names | 571CT1.3.4 |
| Calculated MW | 24579 Da |
| Antigen Region | 150-178 aa |
| Gene ID | 3251 |
|---|---|
| Other Names | Hypoxanthine-guanine phosphoribosyltransferase, HGPRT, HGPRTase, HPRT1, HPRT |
| Target/Specificity | This HPRT1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 150-178 amino acids from human HPRT1. |
| Dilution | WB~~1:500~1600 E~~Use at an assay dependent concentration. |
| Format | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HPRT1 Antibody(Ascites) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HPRT1 |
|---|---|
| Synonyms | HPRT |
| Function | Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway. |
| Cellular Location | Cytoplasm. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage pathway. Mutations in this gene result in Lesch-Nyhan syndrome or gout.
REFERENCES
Garcia, M.G., et al. Nucleosides Nucleotides Nucleic Acids 29 (4-6), 301-305 (2010) :
Torres, R.J., et al. Nucleosides Nucleotides Nucleic Acids 29 (4-6), 295-300 (2010) :
Yamada, Y., et al. Nucleosides Nucleotides Nucleic Acids 29 (4-6), 291-294 (2010) :
Zampieri, M., et al. Mech. Ageing Dev. 131(2):89-95(2010)
Kudo, M., et al. Drug Metab. Pharmacokinet. 24(6):557-564(2009)
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