癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TNFRSF8/CD30 Antibody (Center) (Ascites) 精选
Mouse Monoclonal Antibody (Mab)
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- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P28908 |
| Other Accession | NP_001234.2 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone Names | 595CT15.5.1 |
| Calculated MW | 63747 Da |
| Antigen Region | 294-321 aa |
| Gene ID | 943 |
|---|---|
| Other Names | Tumor necrosis factor receptor superfamily member 8, CD30L receptor, Ki-1 antigen, Lymphocyte activation antigen CD30, CD30, TNFRSF8, CD30, D1S166E |
| Target/Specificity | This TNFRSF8/CD30 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 294-321 amino acids from the Central region of human TNFRSF8/CD30. |
| Dilution | WB~~1:100~1000 E~~Use at an assay dependent concentration. |
| Format | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TNFRSF8/CD30 Antibody (Center) (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TNFRSF8 (HGNC:11923) |
|---|---|
| Function | Receptor for TNFSF8/CD30L (PubMed:8391931). May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa- B (PubMed:8999898). |
| Cellular Location | [Isoform 1]: Cell membrane; Single-pass type I membrane protein |
| Tissue Location | [Isoform 2]: Detected in alveolar macrophages (at protein level). |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
REFERENCES
de Kleer, I., et al. J. Immunol. 185(4):2071-2079(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Halim, M.A., et al. Transplant. Proc. 42(3):801-803(2010)
Dong, L., et al. J. Biomed. Biotechnol. 2010, 569053 (2010) :
Kamali, K., et al. Exp Clin Transplant 7(4):237-240(2009)
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