HNF1A Antibody (Ascites)
Mouse Monoclonal Antibody (Mab)
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Application ![]()
| WB, E |
---|---|
Primary Accession | P20823 |
Other Accession | P15257, P22361, NP_000536.4 |
Reactivity | Human |
Predicted | Mouse, Rat |
Host | Mouse |
Clonality | Monoclonal |
Isotype | IgG1 |
Clone Names | 622CT11.9.6 |
Calculated MW | 67386 Da |
Antigen Region | 177-205 aa |
Gene ID | 6927 |
---|---|
Other Names | Hepatocyte nuclear factor 1-alpha, HNF-1-alpha, HNF-1A, Liver-specific transcription factor LF-B1, LFB1, Transcription factor 1, TCF-1, HNF1A, TCF1 |
Target/Specificity | This HNF1A antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 177-205 amino acids from human HNF1A . |
Dilution | WB~~1:100~1600 E~~Use at an assay dependent concentration. |
Format | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | HNF1A Antibody (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | HNF1A |
---|---|
Synonyms | TCF1 |
Function | Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver (By similarity). Binds to the inverted palindrome 5'- GTTAATNATTAAC-3' (PubMed:10966642, PubMed:12453420). Activates the transcription of CYP1A2, CYP2E1 and CYP3A11 (By similarity). |
Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:10966642, ECO:0000269|PubMed:38018242} |
Tissue Location | Liver. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas.
REFERENCES
Jablonski, K.A., et al. Diabetes 59(10):2672-2681(2010)
Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010)
Speliotes, E.K., et al. Hepatology 52(3):904-912(2010)
Ley, S.H., et al. Cardiovasc Diabetol 9, 39 (2010) :
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :

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