|Application ||WB, E|
|Calculated MW||32462 Da|
|Other Names||Syndecan-1, SYND1, CD138, SDC1, SDC|
|Target/Specificity||Purified His-tagged CD138 protein(Fragment) was used to produced this monoclonal antibody.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD138 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413).|
|Cellular Location||Membrane; Single-pass type I membrane protein. Secreted. Secreted, exosome. Note=Shedding of the ectodomain produces a soluble form.|
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein.
Tsai, E.W., et al. Transplantation 90(8):875-881(2010) Hozumi, K., et al. FEBS Lett. 584(15):3381-3385(2010) Zyada, M.M., et al. Ann Diagn Pathol 14(3):153-161(2010) Al-Shibli, K., et al. APMIS 118(5):371-382(2010) Szumilo, J., et al. Folia Histochem. Cytobiol. 47(4):571-578(2009)