癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MVP Antibody (N-term) (Ascites)
Mouse Monoclonal Antibody (Mab)
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- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q14764 |
| Other Accession | Q62667, Q9EQK5, Q3SYU9, NP_005106.2 |
| Reactivity | Human |
| Predicted | Bovine, Mouse, Rat |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone Names | 599CT2.4.1 |
| Calculated MW | 99327 Da |
| Antigen Region | 12-39 aa |
| Gene ID | 9961 |
|---|---|
| Other Names | Major vault protein, MVP, Lung resistance-related protein, MVP, LRP |
| Target/Specificity | This MVP antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 12-39 amino acids from the N-terminal region of human MVP. |
| Dilution | WB~~1:100~1600 E~~Use at an assay dependent concentration. |
| Format | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MVP Antibody (N-term) (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MVP |
|---|---|
| Synonyms | LRP |
| Function | Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. |
| Cellular Location | Cytoplasm. Nucleus, nuclear pore complex. Cytoplasm, perinuclear region. Note=5% found in the nuclear pore complex (PubMed:15133037). Translocates from the nucleus to the cytoplasm upon EGF treatment (PubMed:16441665) |
| Tissue Location | Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug- resistant cancer cells |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.
REFERENCES
Li, J., et al. Lung Cancer 69(1):116-122(2010)
Liang, P., et al. Biochem. Cell Biol. 88(3):445-450(2010)
An, H.J., et al. Cell Biochem. Funct. 27(5):289-295(2009)
Li, L., et al. Zhonghua Zhong Liu Za Zhi 31(3):199-202(2009)
Lara, P.C., et al. Radiat Oncol 4, 29 (2009) :
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