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LYPD6B Antibody (Center) (Ascites) 精选
Mouse Monoclonal Antibody (Mab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q8NI32 |
| Other Accession | Q9D7F2, NP_808879.2 |
| Reactivity | Human, Mouse |
| Predicted | Rat, Bovine, Canine, Rabbit |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b |
| Clone Names | 634CT7.10.1 |
| Calculated MW | 20656 Da |
| Antigen Region | 79-108 aa |
| Gene ID | 130576 |
|---|---|
| Other Names | Ly6/PLAUR domain-containing protein 6B, LYPD6B |
| Target/Specificity | This LYPD6B antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 79-108 amino acids from the Central region of human LYPD6B. |
| Dilution | WB~~1:500~4000 E~~Use at an assay dependent concentration. |
| Format | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | LYPD6B Antibody (Center) (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | LYPD6B |
|---|---|
| Function | Likely acts as a modulator of nicotinic acetylcholine receptors (nAChRs) activity (PubMed:26586467, PubMed:34631692). In vitro acts on nAChRs in a subtype- and stoichiometry-dependent manner (PubMed:26586467). Modulates specifically alpha-3(3):beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-3(2):alpha- 5:beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn-398 but not its wild-type sequence (PubMed:26586467). However, according to another report in vitro it can weakly inhibits alpha-7 nAChRs (PubMed:34631692). |
| Cellular Location | Cell membrane; Lipid-anchor, GPI- anchor |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The function of this protein is unknown.
REFERENCES
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Ni, J., et al. Mol. Biol. Rep. 36(4):697-703(2009)
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