癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PPT1 Antibody (C-term)
Purified Mouse Monoclonal Antibody (Mab)
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Application 
| WB, FC, IHC-P, E |
|---|---|
| Primary Accession | P50897 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone Names | 1117CT11.2.1.4 |
| Calculated MW | 34193 Da |
| Antigen Region | 1-306 aa |
| Gene ID | 5538 |
|---|---|
| Other Names | Palmitoyl-protein thioesterase 1, PPT-1, Palmitoyl-protein hydrolase 1, PPT1, PPT |
| Target/Specificity | This PPT1 antibody is generated from a mouse immunized with a full-length recombinant protein from human PPT1. |
| Dilution | WB~~1:1000 FC~~1:25 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PPT1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PPT1 |
|---|---|
| Synonyms | CLN1 {ECO:0000303|PubMed:19941651}, PPT |
| Function | Has thioesterase activity against fatty acid thioesters with 14 -18 carbons, including palmitoyl-CoA, S-palmitoyl-N- acetylcysteamine, and palmitoylated proteins (PubMed:12855696, PubMed:26731412, PubMed:8816748). In contrast to PPT2, PPT1 can hydrolyze palmitoylated proteins and palmitoylcysteine (PubMed:12855696). |
| Cellular Location | Lysosome. Secreted Golgi apparatus. Endoplasmic reticulum |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons.
REFERENCES
Vesa J.,et al.Nature 376:584-587(1995).
Crews C.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 93:4316-4319(1996).
Schriner J.E.,et al.Genomics 34:317-322(1996).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
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