癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CAPN6 Antibody
Purified Mouse Monoclonal Antibody (Mab)
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Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q9Y6Q1 |
| Reactivity | Human, Mouse |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone Names | 1395CT446.22.5 |
| Calculated MW | 74576 Da |
| Gene ID | 827 |
|---|---|
| Other Names | Calpain-6, Calpain-like protease X-linked, Calpamodulin, CalpM, CAPN6, CALPM, CANPX |
| Target/Specificity | This CAPN6 antibody is generated from a mouse immunized with a recombinant protein of human CAPN6. |
| Dilution | WB~~1:1000 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CAPN6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CAPN6 |
|---|---|
| Synonyms | CALPM, CANPX |
| Function | Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues (By similarity). |
| Cellular Location | Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, spindle. Note=During mitose associated with the mitotic spindle. At telophase colocalized to the midbody spindle |
| Tissue Location | Expressed only in placenta. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues (By similarity).
REFERENCES
Dear T.N.,et al.Genomics 45:175-184(1997).
Crotty P.L.,et al.Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
Belsito A.,et al.Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
Ross M.T.,et al.Nature 434:325-337(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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