癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
FAT1 Antibody
Purified Mouse Monoclonal Antibody (Mab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q14517 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG1,k |
| Clone Names | 1634CT464.1.9 |
| Calculated MW | 506273 Da |
| Gene ID | 2195 |
|---|---|
| Other Names | Protocadherin Fat 1, Cadherin family member 7, Cadherin-related tumor suppressor homolog, Protein fat homolog, Protocadherin Fat 1, nuclear form, FAT1, CDHF7, FAT |
| Target/Specificity | This FAT1 antibody is generated from a mouse immunized with a recombinant protein between 4203-4539 amino acids from human FAT1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FAT1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FAT1 |
|---|---|
| Synonyms | CDHF7, FAT |
| Function | [Protocadherin Fat 1]: Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. |
| Cellular Location | [Protocadherin Fat 1]: Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Expressed in many epithelial and some endothelial and smooth muscle cells |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact.
REFERENCES
Dunne J.,et al.Genomics 30:207-223(1995).
Hillier L.W.,et al.Nature 434:724-731(2005).
Magg T.,et al.Exp. Cell Res. 307:100-108(2005).
Cantin G.T.,et al.J. Proteome Res. 7:1346-1351(2008).
Hou R.,et al.J. Biol. Chem. 284:6955-6965(2009).
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