癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PDXK Antibody (N-term)
Purified Mouse Monoclonal Antibody (Mab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | O00764 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG1,k |
| Clone Names | 1007CT2.1.1 |
| Calculated MW | 35102 Da |
| Gene ID | 8566 |
|---|---|
| Other Names | Pyridoxal kinase, 2.7.1.35, Pyridoxine kinase, PDXK, C21orf124, C21orf97, PKH, PNK |
| Target/Specificity | This PDXK antibody is generated from a mouse immunized with a recombinant protein between 1-312 amino acids from human PDXK. |
| Dilution | WB~~1:4000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PDXK Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PDXK (HGNC:8819) |
|---|---|
| Function | Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively (Probable) (PubMed:10987144, PubMed:17766369, PubMed:19351586, PubMed:31187503, PubMed:9099727). PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions. |
| Cellular Location | Cytoplasm, cytosol. |
| Tissue Location | Ubiquitous (PubMed:31187503, PubMed:9099727). Highly expressed in testis (PubMed:9099727) |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Required for synthesis of pyridoxal-5-phosphate from vitamin B6.
REFERENCES
Hanna M.C.,et al.J. Biol. Chem. 272:10756-10760(1997).
Fang X.,et al.Asian J. Androl. 6:83-91(2004).
Hattori M.,et al.Nature 405:311-319(2000).
Lee H.-S.,et al.Mol. Cells 10:452-459(2000).
Daub H.,et al.Mol. Cell 31:438-448(2008).
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¥ 1,250.00
Cat# AM8616b
