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>   首页   >   产品   >   一抗   >   细胞生物学   >   PSMC2 Antibody   

PSMC2 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
  • 1 - PSMC2 Antibody AM8659b
    All lanes : Anti-PSMC2 Antibody at 1:1000 dilution + C6 cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 50 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 1 - PSMC2 Antibody AM8659b
    All lanes : Anti-PSMC2 at 1:2000 dilution Lane 1: Jurkat whole cell lysate Lane 2: U-2OS whole cell lysate Lane 3: Hela whole cell lysate Lane 4: MCF-7 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 49 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P35998
Other Accession Q5E9F9, Q4R4R0, P46471
Reactivity Human, Mouse
Predicted Bovine, Mouse
Host Mouse
Clonality monoclonal
Isotype IgG1,k
Clone Names 1851CT193.4.40
Calculated MW 48634 Da
Additional Information
Gene ID 5701
Other Names 26S protease regulatory subunit 7, 26S proteasome AAA-ATPase subunit RPT1, Proteasome 26S subunit ATPase 2, Protein MSS1, PSMC2, MSS1
Target/Specificity This antibody is generated from a mouse immunized with a recombinant protein from human.
Dilution WB~~1:2000
E~~Use at an assay dependent concentration.
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPSMC2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PSMC2
Synonyms MSS1 {ECO:0000303|PubMed:8500623}
Function Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
Cellular Location Cytoplasm. Note=Colocalizes with TRIM5 in cytoplasmic bodies
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. In case of HIV-1 infection, positive modulator of Tat-mediated transactivation.

REFERENCES

Shibuya H.,et al.Nature 357:700-702(1992).
Ohira M.,et al.Cancer Lett. 197:63-68(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 424:157-164(2003).
Scherer S.W.,et al.Science 300:767-772(2003).

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