癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PDCD1LG2 Antibody (N-term) 精选
Purified Mouse Monoclonal Antibody (Mab)
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Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9BQ51 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG1,κ |
| Clone Names | 2011CT265.19.18 |
| Calculated MW | 30957 Da |
| Gene ID | 80380 |
|---|---|
| Other Names | Programmed cell death 1 ligand 2, PD-1 ligand 2, PD-L2, PDCD1 ligand 2, Programmed death ligand 2, Butyrophilin B7-DC, B7-DC, CD273, PDCD1LG2, B7DC, CD273, PDCD1L2, PDL2 |
| Target/Specificity | This PDCD1LG2 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 40-75 amino acids from the N-terminal region of human PDCD1LG2. |
| Dilution | WB~~1:8000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PDCD1LG2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PDCD1LG2 |
|---|---|
| Synonyms | B7DC, CD273, PDCD1L2, PDL2 |
| Function | Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11224527, PubMed:12538684). Acts as a ligand for the inhibitory receptor PDCD1/PD-1, inhibiting T-cell proliferation by blocking cell cycle progression and cytokine production (PubMed:11224527). |
| Cellular Location | [Isoform 3]: Secreted [Isoform 1]: Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Involved in the costimulatory signal, essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity).
REFERENCES
Tseng S.-Y.,et al.J. Exp. Med. 193:839-846(2001).
Latchman Y.,et al.Nat. Immunol. 2:261-268(2001).
He X.-H.,et al.Acta Biochim. Biophys. Sin. 36:284-289(2004).
Humphray S.J.,et al.Nature 429:369-374(2004).
Zhang Z.,et al.Protein Sci. 13:2819-2824(2004).
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