癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GSTA1 Antibody
Purified Mouse Monoclonal Antibody (Mab)
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- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P08263 |
| Reactivity | Human, Rat, Mouse |
| Predicted | Human |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG1,κ |
| Clone Names | 2128CT386.77.4 |
| Calculated MW | 25631 Da |
| Gene ID | 2938 |
|---|---|
| Other Names | Glutathione S-transferase A1, 2.5.1.18, GST HA subunit 1, GST class-alpha member 1, GST-epsilon, GSTA1-1, GTH1, Glutathione S-transferase A1, N-terminally processed, GSTA1 |
| Target/Specificity | This GSTA1 antibody is generated from a mouse immunized with a recombiant protein from the human region of human GSTA1. |
| Dilution | WB~~1:5000 E~~Use at an assay dependent concentration. |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GSTA1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GSTA1 |
|---|---|
| Function | Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds (Probable). Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene- 3,17-dione and may therefore play an important role in hormone biosynthesis (PubMed:11152686). Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)- hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid (PubMed:16624487). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Liver. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
REFERENCES
Tu C.-P.D.,et al.Biochem. Biophys. Res. Commun. 141:229-237(1986).
Rhoads D.M.,et al.Biochem. Biophys. Res. Commun. 145:474-481(1987).
Tu C.-P.D.,et al.Biochem. Soc. Trans. 15:734-736(1987).
Board P.G.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:2377-2381(1987).
Rozen F.,et al.Arch. Biochem. Biophys. 292:589-593(1992).
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