癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SULT2B1
Purified Mouse Monoclonal Antibody (Mab)
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- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | O00204 |
| Reactivity | Human |
| Predicted | Human |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG1,κ |
| Clone Names | 2142CT1553.26.63 |
| Calculated MW | 41308 Da |
| Gene ID | 6820 |
|---|---|
| Other Names | Sulfotransferase family cytosolic 2B member 1, ST2B1, Sulfotransferase 2B1, 2.8.2.2, Alcohol sulfotransferase, Hydroxysteroid sulfotransferase 2, SULT2B1, HSST2 |
| Target/Specificity | This antibody is generated from a mouse immunized with a reconbinant protein from human. |
| Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SULT2B1 is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SULT2B1 |
|---|---|
| Synonyms | HSST2 |
| Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Responsible for the sulfation of cholesterol (PubMed:12145317, PubMed:19589875). Catalyzes sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA) (PubMed:12145317, PubMed:16855051, PubMed:21855633, PubMed:9799594). Preferentially sulfonates cholesterol, while it also has significant activity with pregnenolone and DHEA (PubMed:12145317, PubMed:21855633). Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation (PubMed:28575648). |
| Cellular Location | Cytoplasm, cytosol. Microsome. Nucleus. Note=Phosphorylation of Ser-348 is required for translocation to the nucleus |
| Tissue Location | Expressed in the stratum granulosum-stratum corneum junction in the skin (at protein level) (PubMed:28575648). Expressed highly in placenta, prostate and trachea and lower expression in the small intestine and lung (PubMed:9799594) |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol. Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation (PubMed:28575648).
REFERENCES
Her C.,et al.Genomics 53:284-295(1998).
Grimwood J.,et al.Nature 428:529-535(2004).
Fuda H.,et al.J. Biol. Chem. 277:36161-36166(2002).
He D.,et al.Drug Metab. Dispos. 34:1749-1755(2006).
Salman E.D.,et al.J. Steroid Biochem. Mol. Biol. 127:315-323(2011).
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