癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MAP3K13 (LZK) Antibody (C-term)
Mouse Monoclonal Antibody (Mab)
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Application 
| WB, IF, E |
|---|---|
| Primary Accession | O43283 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgM |
| Clone Names | 810CT26.6.1.1 |
| Calculated MW | 108296 Da |
| Antigen Region | 52-305 aa |
| Gene ID | 9175 |
|---|---|
| Other Names | Mitogen-activated protein kinase kinase kinase 13, Leucine zipper-bearing kinase, Mixed lineage kinase, MLK, MAP3K13 (HGNC:6852) |
| Target/Specificity | Purified His-tagged MAP3K13 protein fragment was used to produced this monoclonal antibody. |
| Dilution | WB~~1:500 IF~~1:100 E~~Use at an assay dependent concentration. |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MAP3K13 (LZK) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MAP3K13 (HGNC:6852) |
|---|---|
| Function | Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB- containing complex that phosphorylates inhibitors of NF-kappa-B. |
| Cellular Location | Cytoplasm. Membrane; Peripheral membrane protein |
| Tissue Location | Expressed in the adult brain, liver, placenta and pancreas, with expression strongest in the pancreas |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.
REFERENCES
Ikeda A., et al. J. Biochem. 130:773-781(2001).
Masaki M., et al. Eur. J. Biochem. 270:76-83(2003).
Greenman C., et al. Nature 446:153-158(2007).
Sakuma H., et al. J. Biol. Chem. 272:28622-28629(1997).
Ota T., et al. Nat. Genet. 36:40-45(2004).
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