癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Norepinephrine Transporter Antibody
Mouse monoclonal antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | O55192 |
| Reactivity | Mouse, Rat |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG2b |
| Clone Names | NET-05 |
| Calculated MW | 69255 Da |
| Gene ID | 20538 |
|---|---|
| Gene Name | SLC6A2 |
| Other Names | Sodium-dependent noradrenaline transporter, Norepinephrine transporter, NET, Solute carrier family 6 member 2, Slc6a2 |
| Target/Specificity | Synthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH. |
| Dilution | WB~~ 1:2000 |
| Format | Protein G purified culture supernatant. |
| Antibody Specificity | Specific for the ~55kDa Norepinephrine Transporter in Western blots ofmouse and rat cortex homogenate. No reactivity with tissue or cells from NET knock-out mice. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Norepinephrine Transporter Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Shipping | Blue Ice |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Norepinephrine Transporter [NET] (or noradrenaline transporter (NAT)) is a monoamine transporter that transports the neurotransmitter noradrenaline from the synapse back to its vesicles for storage until later use. It also appears to transport the neurotransmitter dopamine in the same way, but to a lesser degree. Studies have shown a decrease in NET levels in the locus coeruleus in patients diagnosed with major depression (Klimek et al., 1997). Cocaine, amphetamines and many therapeutic antidepressants, such as the SNRIs (Serotonin-norepinephrine reuptake inhibitors) and the tricyclic antidepressants (TCAs) act to raise noradrenaline. Furthermore, deficits in the NET gene have been associated with ADHD (Kim et al., 2006).
REFERENCES
Klimek V, Stockmeier C, Overholser J, Meltzer HY, Kalka S, Dilley G, Ordway GA (1997)
Reduced levels of norepinephrine transporters in the locus coeruleus in major depression. J.
Neurosci. 17(21):8451-8458
Kim CH, Hahn MK, Joung Y, Anderson SL, Steele AH, Mazei-Robinson MS, Gizer I, Teicher
MH, Cohen BM, Robertson D, Waldman ID, Blakely RD, Kim KS (2006) A Polymorphism in the
norepinephrine transporter gene alters promoter activity and is associated with attention-deficit
hyperactivity disorder. Proc Nat’l Acad Sci USA 103(50):19164-9.
终于等到您。ABCEPTA（百远生物）抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息，您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。
如有疑问，联系：0512-88856768 tech-china@abcepta.com.
