癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-ABCA4 (Rim Protein) Antibody
Our Anti-ABCA4 (Rim Protein) primary antibody from PhosphoSolutions is mouse monoclonal. It detects
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Application 
| WB, IHC |
|---|---|
| Primary Accession | F1MWM0 |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone Names | 3F4 |
| Calculated MW | 257376 Da |
| Gene ID | 281584 |
|---|---|
| Other Names | ABC 10 antibody, ABC A4 antibody, ABC transporter retinal-specific antibody, ABC10 antibody, ABCA 4 antibody, abcA4 antibody, ABCA4_HUMAN antibody, ABCR antibody, ARMD 2 antibody, ARMD2 antibody, ATP binding cassette 10 antibody, ATP binding cassette sub family A member 4 antibody, ATP binding cassette sub family A member4 antibody, ATP binding cassette transporter antibody, ATP binding cassette transporter retinal specific antibody, ATP binding cassette, sub family A (ABC1) member 4 antibody, ATP binding cassette sub family A (ABC1) member4 antibody, ATP binding cassette10 antibody, ATP binding transporter retina specific antibody, ATP-binding cassette sub-family A member 4 antibody, CORD 3 antibody, CORD3 antibody, DKFZp781N1972 antibody, FFM antibody, FLJ17534 antibody, Photoreceptor rim protein antibody, Retina specific ABC transporter antibody, Retinal specific ATP binding cassette transporter antibody, Retinal-specific ATP-binding cassette transporter antibody, RIM ABC transporter antibody, RIM protein antibody, RmP antibody, RP 19 antibody, RP19 antibody, Stargardt disease protein antibody, STGD antibody, STGD1 antibody |
| Target/Specificity | ABCA4 (ATP-binding cassette, sub-family A (ABC1), member 4, Rim Protein) is a member of the superfamily of ATP-binding cassette (ABC) transporters (Illing et al., 1997). ABC proteins transport various molecules across extra- and intracellular membranes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essential molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease and are associated with retinitis pigmentosa-19 and age-related macular degeneration (Wiszniewski et al., 2003). Defects in ABCA4 are the cause of Stargardt disease type 1 (STGD1) (Molday et al., 2000). STGD is one of the most frequent causes of macular degeneration in childhood. Defects in ABCA4 are also known to cause fundus flavimaculatus (FFM), age-related macular degeneration type 2 (ARMD2) and cone-rod dystrophy type 3 (CORD3) (Klevering et al., 2005). |
| Dilution | WB~~1:1000 IHC~~1:100~500 |
| Format | Protein G Purified |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Anti-ABCA4 (Rim Protein) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Shipping | Blue Ice |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
ABCA4 (ATP-binding cassette, sub-family A (ABC1), member 4, Rim Protein) is a member of the superfamily of ATP-binding cassette (ABC) transporters (Illing et al., 1997). ABC proteins transport various molecules across extra- and intracellular membranes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essential molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease and are associated with retinitis pigmentosa-19 and age-related macular degeneration (Wiszniewski et al., 2003). Defects in ABCA4 are the cause of Stargardt disease type 1 (STGD1) (Molday et al., 2000). STGD is one of the most frequent causes of macular degeneration in childhood. Defects in ABCA4 are also known to cause fundus flavimaculatus (FFM), age-related macular degeneration type 2 (ARMD2) and cone-rod dystrophy type 3 (CORD3) (Klevering et al., 2005).
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