癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-p70 S6 Kinase (Ser398) Antibody
Our Anti-p70 S6 Kinase (Ser398) rabbit polyclonal phosphospecific primary antibody from PhosphoSolut
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | H1ZYE3 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Other Names | 70 kDa ribosomal protein S6 kinase 2 antibody, EC 2.7.11.1 antibody, KS6B2_HUMAN antibody, p70 beta antibody, p70 ribosomal S6 kinase beta antibody, p70 S6 kinase beta antibody, p70 S6K-beta antibody, p70 S6KB antibody, p70 S6Kbeta antibody, p70(S6K) beta antibody, p70-beta antibody, p70-S6K 2 antibody, P70S6K2 antibody, p70S6Kb antibody, Ribosomal protein S6 kinase 70kDa polypeptide 2 antibody, Ribosomal protein S6 kinase B2 antibody, Ribosomal protein S6 kinase beta 2 antibody, Ribosomal protein S6 kinase beta-2 antibody, Rps6kb2 antibody, S6 kinase related kinase antibody, S6 kinase-related kinase antibody, S6K beta 2 antibody, S6K beta antibody, S6K-beta antibody, S6K-beta-2 antibody, S6K2 antibody, Serine/threonine protein kinase 14 beta antibody, Serine/threonine-protein kinase 14B antibody, SRK antibody, STK14B antibody |
|---|---|
| Target/Specificity | p70 S6 kinase (p70 S6K) is activated in a signaling pathway that includes mTOR and is a mitogen-activated Ser/Thr protein kinase that is required for cell growth and G1 cell cycle progression (Xio et al., 2009). p70 S6K is controlled by multiple phosphorylation events located within the catalytic, linker and pseudosubstrate domains and subsequently phosphorylates specifically ribosomal protein S6 (Saitoh et al., 2002). Phosphorylation of Thr-229 in the catalytic domain and Thr-389 in the linker domain are most critical for kinase function. Inhibition of p70 activity inhibits the entry into S phase of the cell cycle and exhibits cell cycle arrest at G0/G1 phase, suggesting that the activation of p70 S6k plays an obligatory role in mediating mitogenic signals during cell activation (Xio et al., 2009). |
| Dilution | WB~~1:1000 |
| Format | Antigen Affinity Purified from Pooled Serum |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Anti-p70 S6 Kinase (Ser398) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Shipping | Blue Ice |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
p70 S6 kinase (p70 S6K) is activated in a signaling pathway that includes mTOR and is a mitogen-activated Ser/Thr protein kinase that is required for cell growth and G1 cell cycle progression (Xio et al., 2009). p70 S6K is controlled by multiple phosphorylation events located within the catalytic, linker and pseudosubstrate domains and subsequently phosphorylates specifically ribosomal protein S6 (Saitoh et al., 2002). Phosphorylation of Thr-229 in the catalytic domain and Thr-389 in the linker domain are most critical for kinase function. Inhibition of p70 activity inhibits the entry into S phase of the cell cycle and exhibits cell cycle arrest at G0/G1 phase, suggesting that the activation of p70 S6k plays an obligatory role in mediating mitogenic signals during cell activation (Xio et al., 2009).
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