癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-SAP49 Antibody
Our Anti-SAP49 primary antibody from PhosphoSolutions is mouse monoclonal. It detects human, mouse,
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC, ICC |
|---|---|
| Primary Accession | Q15427 |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b |
| Clone Names | 3A1 |
| Calculated MW | 44386 Da |
| Gene ID | 10262 |
|---|---|
| Other Names | AFD1 antibody, Hsh49 antibody, MGC10828 antibody, Pre mRNA splicing factor SF3b 49 kDa subunit antibody, Pre-mRNA-splicing factor SF3b 49 kDa subunit antibody, SAP 49 antibody, SAP49 antibody, Sf3b4 antibody, SF3B4 antibody, SF3B4_HUMAN antibody, SF3b49 antibody, SF3b50 antibody, Spliceosomal protein antibody, Spliceosome associated protein (U2 snRNP) antibody, Spliceosome associated protein 49 antibody, Spliceosome-associated protein 49 antibody, Splicing factor 3b subunit 4 49kDa antibody, Splicing factor 3B subunit 4 antibody |
| Target/Specificity | The spliceosome associated protein of ~49 kDa (SAP49), also known as SF3B4, is a widely expressed nuclear splicing factor that has been shown to have RNA binding activity as well as direct interaction with SAP145 (Champion-Arnaud and Reed 1994). The SAP145-SAP49 complex has recently been implicated in cell cycle progression as Vpr (viral protein 1 of HIV-1) has been shown to bind SAP145 thus interfering with the proper formation and functioning of the SAP145-SAP49 complex (Terada and Yasuda 2006). |
| Dilution | WB~~1:1000 IHC~~1:100~500 ICC~~N/A |
| Format | Protein G Purified |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Anti-SAP49 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Shipping | Blue Ice |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The spliceosome associated protein of ~49 kDa (SAP49), also known as SF3B4, is a widely expressed nuclear splicing factor that has been shown to have RNA binding activity as well as direct interaction with SAP145 (Champion-Arnaud and Reed 1994). The SAP145-SAP49 complex has recently been implicated in cell cycle progression as Vpr (viral protein 1 of HIV-1) has been shown to bind SAP145 thus interfering with the proper formation and functioning of the SAP145-SAP49 complex (Terada and Yasuda 2006).
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