癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-SARM1 Antibody
Our Anti-SARM1 Antibody primary antibody from PhosphoSolutions is rabbit polyclonal. It detects huma
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, ICC |
|---|---|
| Primary Accession | Q6SZW1 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 79388 Da |
| Gene ID | 23098 |
|---|---|
| Other Names | FLJ36296 antibody, KIAA0524 antibody, MyD88-5 antibody, SAM and ARM-containing protein antibody, SAM domain-containing protein 2 antibody, SAMD2 antibody, SARM 1 antibody, SARM1 antibody, SARM1_HUMAN antibody, Sterile alpha and Armadillo repeat protein antibody, sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila antibody, sterile alpha and HEAT/Armadillo motifs-containing protein antibody, sterile alpha and TIR motif containing 1 antibody, Sterile alpha and TIR motif-containing protein 1 antibody, Sterile alpha and TIR motifs-containing protein 1 antibody, Sterile alpha motif domain-containing protein 2 antibody, Tir-1 homolog antibody |
| Target/Specificity | NAD(+) hydrolase sterile alpha and TIR motif-containing protein 1 (SARM1), is the fifth member of the Toll/Il-1 Receptor (TIR) domain protein family. The highly conserved 724 amino acid protein is predominantly expressed in the brain, kidney and liver (Mink, M., et al 2001). Furthermore, SARM1 is enriched in the cytoplasm, mitchondria, and the axons, dendrites, and synapses of neurons (Panneerselvam, P., et al, 2012). SARM1 plays a key role in axonal degeneration by catalyzing the cleavage of NAD+ into ADPR, cADPR, and nicotinamide in response to injury triggering Wallerian degeneration (Gerdts, J. et al 2015). SARM1 has also been shown to activate neuronal cell death in response to stress (Peng, J. et al. 2010). |
| Dilution | WB~~1:1000 ICC~~N/A |
| Format | Antigen Affinity Purified from Pooled Serum |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Anti-SARM1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Shipping | Blue Ice |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
NAD(+) hydrolase sterile alpha and TIR motif-containing protein 1 (SARM1), is the fifth member of the Toll/Il-1 Receptor (TIR) domain protein family. The highly conserved 724 amino acid protein is predominantly expressed in the brain, kidney and liver (Mink, M., et al 2001). Furthermore, SARM1 is enriched in the cytoplasm, mitchondria, and the axons, dendrites, and synapses of neurons (Panneerselvam, P., et al, 2012). SARM1 plays a key role in axonal degeneration by catalyzing the cleavage of NAD+ into ADPR, cADPR, and nicotinamide in response to injury triggering Wallerian degeneration (Gerdts, J. et al 2015). SARM1 has also been shown to activate neuronal cell death in response to stress (Peng, J. et al. 2010).
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