癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-Ubiquitin C-terminal Hydrolase 1 (UCHL1) Antibody
Our Anti-Ubiquitin C-terminal Hydrolase 1 (UCHL1) primary antibody from PhosphoSolutions is chicken
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC, ICC |
|---|---|
| Primary Accession | P09936 |
| Reactivity | Pig |
| Host | Chicken |
| Clonality | Polyclonal |
| Isotype | IgY |
| Calculated MW | 24824 Da |
| Gene ID | 7345 |
|---|---|
| Other Names | Epididymis luminal protein 117 antibody, Epididymis secretory protein Li 53 antibody, HEL 117 antibody, HEL S 53 antibody, NDGOA antibody, Neuron cytoplasmic protein 9.5 antibody, OTTHUMP00000218137 antibody, OTTHUMP00000218139 antibody, OTTHUMP00000218140 antibody, OTTHUMP00000218141 antibody, Park 5 antibody, PARK5 antibody, PGP 9.5 antibody, PGP9.5 antibody, PGP95 antibody, Protein gene product 9.5 antibody, Ubiquitin C terminal esterase L1 antibody, Ubiquitin C terminal hydrolase antibody, Ubiquitin C terminal hydrolase L1 antibody, Ubiquitin carboxyl terminal esterase L1 antibody, Ubiquitin carboxyl terminal hydrolase isozyme L1 antibody, Ubiquitin carboxyl-terminal hydrolase isozyme L1 antibody, Ubiquitin thioesterase L1 antibody, Ubiquitin thiolesterase antibody, Ubiquitin thiolesterase L1 antibody, UCH-L1 antibody, UCHL1 antibody, UCHL1_HUMAN antibody |
| Target/Specificity | Ubiquitin C-terminal hydrolase 1 (UCHL1) is also known as ubiquitin carboxyl esterase L1, ubiquitin thiolesterase, neuron-specific protein PGP9.5 and Park5. It was originally identified as a major component of the neuronal cytoplasm from 2-dimensional gel analysis of brain tissues, and was given the name PGP9.5 (1). It was later found that ubiquitin C-terminal hydrolase enzyme activity was associated with the PGP9.5 protein (2). The ubiquitin C-terminal hydrolases cleave ubiquitin from other molecules. Regulation of the ubiquitin pathway is very important and many disease states are associated with defects in this pathway. Genetic knockout of UCHL1 in mice results in a motor neuron degeneration similar to the spontaneous gracile axonal dystrophy (gad) mutant mice (3). Point mutations in the UCHL1 gene are associated with some forms of human Parkinson's disease (4). Since UCHL1 is heavily expressed in neurons, it is released in large amounts following injury or degeneration, so the detection of UCHL1 in CSF and other bodily fluids can be used as a biomarker. |
| Dilution | WB~~1:1000 IHC~~1:100~500 ICC~~N/A |
| Format | Total IgY fraction |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Anti-Ubiquitin C-terminal Hydrolase 1 (UCHL1) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Shipping | Blue Ice |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Ubiquitin C-terminal hydrolase 1 (UCHL1) is also known as ubiquitin carboxyl esterase L1, ubiquitin thiolesterase, neuron-specific protein PGP9.5 and Park5. It was originally identified as a major component of the neuronal cytoplasm from 2-dimensional gel analysis of brain tissues, and was given the name PGP9.5 (1). It was later found that ubiquitin C-terminal hydrolase enzyme activity was associated with the PGP9.5 protein (2). The ubiquitin C-terminal hydrolases cleave ubiquitin from other molecules. Regulation of the ubiquitin pathway is very important and many disease states are associated with defects in this pathway. Genetic knockout of UCHL1 in mice results in a motor neuron degeneration similar to the spontaneous gracile axonal dystrophy (gad) mutant mice (3). Point mutations in the UCHL1 gene are associated with some forms of human Parkinson's disease (4). Since UCHL1 is heavily expressed in neurons, it is released in large amounts following injury or degeneration, so the detection of UCHL1 in CSF and other bodily fluids can be used as a biomarker.
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