癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KSHV K8a Antibody
Purified Mouse Monoclonal Antibody
- 产品详情
- 实验流程
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | Q2HR82 |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 8C12G10G1 |
| Isotype | IgG2a |
| Calculated MW | 31574 Da |
| Description | Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi’s sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman’s disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. KSHV K8 and K8.1 open reading frames are juxtaposed and span from nucleotide (nt) 74850 to 76695 of the virus genome. A K8 pre-mRNA overlaps the entire K8.1 coding region, and alternative splicing of KSHV K8 and K8.1 pre-mRNAs each produces three isoforms (α, β, and γ) of the mRNAs. |
| Immunogen | Purified recombinant fragment of KSHV K8α expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
| Gene ID | 4961462 |
|---|---|
| Other Names | E3 SUMO-protein ligase K-bZIP, 6.3.2.-, K8 |
| Dilution | WB~~1/500 - 1/2000 IHC~~1/200 - 1/1000 E~~N/A |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KSHV K8a Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | K8 |
|---|---|
| Function | SUMO E3 ligase that plays a role in viral gene regulation and is essential for viral reactivation (PubMed:17652396, PubMed:20034935). Disrupts host G1 cell cycle control thus allowing viral transcription and translation to proceed at the early stages of infection. Catalyzes its own SUMO modification as well as that of its interacting partners such as host TP53 and RB1. Regulates viral gene expression and reactivation and may mediate the SUMOylation of viral promoters in the low methylated 'Lys-9' histone H3 (H3K9me) region which results in a diminution of viral gene expression after reactivation (PubMed:26197391). SUMOylates also host histone lysine demethylase 4A/KDM4A, an essential step for complete enrichment of SUMO-2/3 on the viral genome during viral transactivation and reactivation (PubMed:28212444). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
1. James J et al. Proc. Natl. Acad. Sci Vol. 1996. 93, pp. 14862-14867.
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