癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
REG1A Antibody
Purified Mouse Monoclonal Antibody
- 产品详情
- 实验流程
Application 
| IHC, ICC, E |
|---|---|
| Primary Accession | P05451 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 1A4 |
| Isotype | IgG1 |
| Calculated MW | 18731 Da |
| Description | REG1A (regenerating islet-derived 1 alpha), also known as PTP, PSP, is a member of the Reg family of secreted proteins with a C-type lectin domain. REG1A is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis.Due to variable glycosylation, pancreatic REG1A exists as multiple species of 16 - 18 kDa. REG1A promotes the maintenance and growth of pancreatic islet β-cells and intestinal villi. It is upregulated in pancreatitis and some carcinomas. REG1A is an antigenic target in autoimmune diabetes. |
| Immunogen | Purified recombinant fragment of human REG1A fused with hIgGFc tag expressed in HEK293 cell line. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
| Gene ID | 5967 |
|---|---|
| Other Names | Lithostathine-1-alpha, Islet cells regeneration factor, ICRF, Islet of Langerhans regenerating protein, REG, Pancreatic stone protein, PSP, Pancreatic thread protein, PTP, Regenerating islet-derived protein 1-alpha, REG-1-alpha, Regenerating protein I alpha, REG1A, PSPS, PSPS1, REG |
| Dilution | IHC~~1/200 - 1/1000 ICC~~N/A E~~N/A |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | REG1A Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | REG1A |
|---|---|
| Synonyms | PSPS, PSPS1, REG |
| Function | Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration. |
| Cellular Location | Secreted. |
| Tissue Location | In pancreatic acinar cells and, in lower levels, in brain. Enhanced expression of PSP-related transcripts and intraneuronal accumulation of PSP-like proteins is found in brain from Alzheimer disease and Down syndrome patients. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
1. Pancreas. 2004 Jul;29(1):14-21. 2. Int J Cancer. 2008 Jul 15;123(2):409-13.
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