癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
EGF Antibody
Purified Mouse Monoclonal Antibody
- 产品详情
- 实验流程
Application 
| WB, ICC, E |
|---|---|
| Primary Accession | P01133 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 4E11 |
| Isotype | IgG1 |
| Calculated MW | 133994 Da |
| Description | Epidermal growth factor has a profound effect on the differentiation of specific cells in vivo and is a potent mitogenic factor for a variety of cultured cells of both ectodermal and mesodermal origin. The EGF precursor is believed to exist as a membrane-bound molecule which is proteolytically cleaved to generate the 53-amino acid peptide hormone that stimulates cells to divide. |
| Immunogen | Purified recombinant fragment of human EGF expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
| Gene ID | 1950 |
|---|---|
| Other Names | Pro-epidermal growth factor, EGF, Epidermal growth factor, Urogastrone, EGF |
| Dilution | WB~~1/500 - 1/2000 ICC~~N/A E~~N/A |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | EGF Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | EGF |
|---|---|
| Function | EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro (PubMed:10964941). |
| Cellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Location | Expressed in kidney, salivary gland, cerebrum and prostate. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
1. Biochem J. 1992 Dec 1;288 ( Pt 2):395-405. 2. Oncogene. 2000 Mar 16;19(12):1509-18. 3. Nature. 2002 Mar 14;416(6877):183-7. 4. Radiat Res. 2003 Apr;159(4):439-52.
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