癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CCNB1 Antibody
Purified Mouse Monoclonal Antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC, E |
|---|---|
| Primary Accession | P14635 |
| Reactivity | Human, Rat |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 5G6 |
| Isotype | IgG1 |
| Calculated MW | 48337 Da |
| Description | The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. (provided by RefSeq) It has higher expression in tumor tissues . |
| Immunogen | Purified recombinant fragment of human CCNB1 expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
| Gene ID | 891 |
|---|---|
| Other Names | G2/mitotic-specific cyclin-B1, CCNB1, CCNB |
| Dilution | WB~~1/500 - 1/2000 FC~~1/200 - 1/400 ICC~~N/A E~~N/A |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CCNB1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CCNB1 |
|---|---|
| Synonyms | CCNB |
| Function | Essential for the control of the cell cycle at the G2/M (mitosis) transition. |
| Cellular Location | Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
1. Br J Cancer. 2009 Oct 20;101(8):1461-8. 2. Cancer Res. 2010 Feb 1;70(3):1265-74. 3. J Biol Chem. 2010 Jun 4;285(23):17833-45.
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