癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SOX2 Antibody
Purified Mouse Monoclonal Antibody
- 产品详情
- 实验流程
Application 
| WB, IHC, ICC, E |
|---|---|
| Primary Accession | P48432 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 10F10 |
| Isotype | IgG1 |
| Calculated MW | 34454 Da |
| Description | Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. |
| Immunogen | Purified recombinant fragment of human SOX2 expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
| Gene ID | 20674 |
|---|---|
| Other Names | Transcription factor SOX-2, Sox2, Sox-2 |
| Dilution | WB~~1/500 - 1/2000 IHC~~1/500 - 1/2000 ICC~~N/A E~~N/A |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SOX2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Sox2 |
|---|---|
| Synonyms | Sox-2 |
| Function | Transcription factor that forms a trimeric complex with POU5F1 (OCT3/4) on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (PubMed:15863505, PubMed:17097055, PubMed:19740739, PubMed:32703285). Binds to the proximal enhancer region of NANOG (PubMed:15863505). Critical for early embryogenesis and for embryonic stem cell pluripotency (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (PubMed:22198669). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). May function as a switch in neuronal development (By similarity). |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:17097055, ECO:0000269|PubMed:19349578, ECO:0000269|PubMed:32127020}. Cytoplasm Note=Nuclear import is facilitated by XPO4, a protein that usually acts as a nuclear export signal receptor. |
| Tissue Location | Expressed in the cochlea (at protein level) (PubMed:32127020). Expressed in the brain and retina (PubMed:15863505, PubMed:7590241). A very low level of expression is seen in the stomach and lung (PubMed:15863505, PubMed:7590241). Expressed in the kidney (PubMed:15863505). |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
1. Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18396-401. 2. J Biol Chem. 2008 Nov 28;283(48):33730-5. 3. Nature. 2008 Oct 23;455(7216):1124-8.
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