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CEA Antibody

Purified Mouse Monoclonal Antibody

     
  • 10 - CEA Antibody AO1508a

    Red: Control Antigen (100ng);
    Purple: Antigen (10ng);
    Green: Antigen (50ng);
    Blue: Antigen (100ng);

  • 1 - CEA Antibody AO1508a
    Figure 1: Western blot analysis using CEA mAb against HEK293 (1) and CEA(AA: 460-600)-hIgGFc transfected HEK293 (2) cell lysate.
  • 3 - CEA Antibody AO1508a
    Figure 2: Immunofluorescence analysis of PANC-1 cells using CEA mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, ICC, E
Primary Accession P06731
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 3G12
Isotype IgG1
Calculated MW 76796 Da
Description Carcino Embryonic Antigen (CEA) is synthesised during development in the fetal gut, and is re-expressed in increased amounts in intestinal carcinomas and several other tumors. Antibodies to CEA are useful in identifying the origin of various metastatic adenocarcinomas and in distinguishing pulmonary adenocarcinomas (60 to 70% are CEA+) from pleural mesotheliomas (rarely or weakly CEA+). The carcinoembryonic antigen (CEA) is a member of a large family of glycoproteins and a useful tumor marker for adenocarcinoma. Tissue specificity: Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.
Immunogen Purified recombinant fragment of human CEA expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 1048
Other Names Carcinoembryonic antigen-related cell adhesion molecule 5, Carcinoembryonic antigen, CEA, Meconium antigen 100, CD66e, CEACAM5, CEA
Dilution WB~~1/500 - 1/2000
ICC~~N/A
E~~1/10000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCEA Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CEACAM5 (HGNC:1817)
Function Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:10864933, PubMed:10910050, PubMed:2803308). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050).
Cellular Location Cell membrane; Lipid-anchor, GPI-anchor. Apical cell membrane. Cell surface Note=Localized to the apical glycocalyx surface
Tissue Location Expressed in columnar epithelial and goblet cells of the colon (at protein level) (PubMed:10436421). Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

REFERENCES

1. Scand J Clin Lab Invest. 2008;68(8):703-13. 2. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2008 Apr;24(4):370-2. Chinese.

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