癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
E7 Antibody
Purified Mouse Monoclonal Antibody
- 产品详情
- 实验流程
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | P03129 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 6F3 |
| Isotype | IgG1 |
| Calculated MW | 11022 Da |
| Description | E7 transforming protein (Human papillomavirus type 16). |
| Immunogen | Purified recombinant fragment of E7 expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
| Gene ID | 1489079 |
|---|---|
| Other Names | Protein E7, E7 |
| Dilution | WB~~1/500 - 1/2000 IHC~~1/500 - 1/2000 E~~1/10000 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | E7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | E7 {ECO:0000255|HAMAP-Rule:MF_04004} |
|---|---|
| Function | Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta). |
| Cellular Location | Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04004, ECO:0000269|PubMed:18996550, ECO:0000269|PubMed:3033296}. Host nucleus {ECO:0000255|HAMAP-Rule:MF_04004, ECO:0000269|PubMed:18996550} Note=Predominantly found in the host nucleus. {ECO:0000255|HAMAP- Rule:MF_04004, ECO:0000269|PubMed:18996550} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
1. Methods Mol Med. 2005;119:363-79. 2. Viral Immunol. 2006 Summer;19(3):468-80.
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