PON1 Antibody
Purified Mouse Monoclonal Antibody
- 产品详情
- 实验流程
- 背景知识
Application ![]()
| WB, IHC, FC, E |
---|---|
Primary Accession | P27169 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 4G8A12 |
Isotype | IgG1 |
Calculated MW | 39731 Da |
Description | The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3. |
Immunogen | Purified recombinant fragment of human PON1 (AA: 20-155) expressed in E. Coli. |
Formulation | Ascitic fluid containing 0.03% sodium azide. |
Gene ID | 5444 |
---|---|
Other Names | Serum paraoxonase/arylesterase 1, PON 1, 3.1.1.2, 3.1.1.81, 3.1.8.1, Aromatic esterase 1, A-esterase 1, K-45, Serum aryldialkylphosphatase 1, PON1, PON |
Dilution | WB~~1/500 - 1/2000 IHC~~1/200 - 1/1000 FC~~1/200 - 1/400 E~~1/10000 |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PON1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PON1 |
---|---|
Synonyms | PON |
Function | Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation. |
Cellular Location | Secreted, extracellular space. |
Tissue Location | Plasma, associated with HDL (at protein level). Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3. ;
REFERENCES
1. Redox Rep. 2012;17(5):214-8. 2. Cancer Epidemiol. 2012 Apr;36(2):e101-3.

终于等到您。ABCEPTA(百远生物)抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息,您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。
如有疑问,联系:0512-88856768 tech-china@abcepta.com.