CAMK2G Antibody
Purified Mouse Monoclonal Antibody
- 产品详情
- 实验流程
- 背景知识
Application ![]()
| WB, E |
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Primary Accession | Q13555 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 6A4A10 |
Isotype | IgG1 |
Calculated MW | 62607 Da |
Description | The product of this gene is one of the four subunits of an enzyme which belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Many alternatively spliced transcripts encoding different isoforms have been described but the full-length nature of all the variants has not been determined. |
Immunogen | Purified recombinant fragment of human CAMK2G (AA: 322-481) expressed in E. Coli. |
Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Gene ID | 818 |
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Other Names | Calcium/calmodulin-dependent protein kinase type II subunit gamma, CaM kinase II subunit gamma, CaMK-II subunit gamma, 2.7.11.17, CAMK2G, CAMK, CAMK-II, CAMKG |
Dilution | WB~~1/500 - 1/2000 E~~1/10000 |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CAMK2G Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CAMK2G |
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Synonyms | CAMK, CAMK-II, CAMKG |
Function | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (PubMed:16690701). In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). |
Cellular Location | Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side |
Tissue Location | Expressed in skeletal muscle. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of the intermediate filament protein family and is expressed primarily in nerve cells. ; ;
REFERENCES
1. Blood. 2012 Dec 6;120(24):4829-39. 2. Diabetologia. 2002 Apr;45(4):580-3.

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