OTUD4 Antibody
Purified Mouse Monoclonal Antibody
- 产品详情
- 实验流程
Application ![]()
| WB, FC, E |
---|---|
Primary Accession | Q01804 |
Reactivity | Human, Rat |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 3B12G11 |
Isotype | IgG1 |
Calculated MW | 124045 Da |
Description | Alternatively spliced transcript variants have been found for this gene. The smaller protein isoform encoded by the shorter transcript variant is found only in HIV-1 infected cells. |
Immunogen | Purified recombinant fragment of human OTUD4 (AA: 815-1049) expressed in E. Coli. |
Formulation | Purified antibody in PBS with 0.05% sodium azide |
Gene ID | 54726 |
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Other Names | OTU domain-containing protein 4, 3.4.19.12, HIV-1-induced protein HIN-1, OTUD4, HIN1, KIAA1046 |
Dilution | WB~~1/500 - 1/2000 FC~~1/200 - 1/400 E~~1/10000 |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | OTUD4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | OTUD4 (HGNC:24949) |
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Function | Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein (PubMed:23827681, PubMed:25944111, PubMed:29395066). May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators (PubMed:29395066). Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase- substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). |
Cellular Location | Cytoplasm. Nucleus. Note=Primarily cytoplasmic |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
1.EMBO J. 2015 Jun 12;34(12):1687-703.

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