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CHGA Antibody

Purified Mouse Monoclonal Antibody

     
  • 10 - CHGA Antibody AO2257a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • 1 - CHGA Antibody AO2257a
    Figure 1: Western blot analysis using CHGA mAb against human CHGA recombinant protein. (Expected MW is 43.6 kDa)
  • 1 - CHGA Antibody AO2257a
    Figure 2: Western blot analysis using CHGA mouse mAb against MOLT4 (1), SK-N-SH (2), HepG2 (3), PC-12 (4), and C6 (5) cell lysate.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P10645
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Clone Names 1A6B6
Isotype IgG1
Calculated MW 50688 Da
Description The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown.
Immunogen Purified recombinant fragment of human CHGA (AA: 87-252 ) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 1113
Other Names Chromogranin-A, CgA, Pituitary secretory protein I, SP-I, Vasostatin-1, Vasostatin I, Vasostatin-2, Vasostatin II, EA-92, ES-43, Pancreastatin, SS-18, WA-8, WE-14, LF-19, AL-11, GV-19, GR-44, ER-37, CHGA
Dilution WB~~1/500 - 1/2000
E~~1/10000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCHGA Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CHGA
Function [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.
Cellular Location [Serpinin]: Secreted {ECO:0000250|UniProtKB:P26339}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:P26339}. Note=Pyroglutaminated serpinin localizes to secretory vesicle. {ECO:0000250|UniProtKB:P26339}
Tissue Location Detected in cerebrospinal fluid (at protein level) (PubMed:25326458). Detected in urine (at protein level) (PubMed:37453717).
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

REFERENCES

1.Cell Signal. 2012 Jan;24(1):233-46. 2.J Endocrinol Invest. 2010 Mar;33(3):186-91.

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