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PAX3 Antibody

Purified Mouse Monoclonal Antibody

     
  • 10 - PAX3 Antibody AO2314a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • 1 - PAX3 Antibody AO2314a
    Figure 1: Western blot analysis using PAX3 mAb against human PAX3 recombinant protein. (Expected MW is 32.6 kDa)
  • 1 - PAX3 Antibody AO2314a
    Figure 2: Western blot analysis using PAX3 mAb against HEK293 (1) and PAX3 (AA: 142-203)-hIgGFc transfected HEK293 (2) cell lysate.
  • 1 - PAX3 Antibody AO2314a
    Figure 3: Western blot analysis using PAX3 mouse mAb against Mouse brain (1), Rat spleen (2), Mouse liver (3) cell lysate.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P23760
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Clone Names 7D8G7
Isotype IgG1
Calculated MW 52968 Da
Description This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini.
Immunogen Purified recombinant fragment of human PAX3 (AA: 142-203) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 5077
Other Names Paired box protein Pax-3, HuP2, PAX3, HUP2
Dilution WB~~1/500 - 1/2000
E~~1/10000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPAX3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PAX3
Synonyms HUP2
Function Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, acting synergistically with SOX10 (PubMed:21965087).
Cellular Location Nucleus.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

REFERENCES

1. Cell Death Differ. 2012 Apr;19(4):616-22. 2. Biochem Biophys Res Commun. 2011 Aug 12;411(4):832-7.

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