PAX3 Antibody
Purified Mouse Monoclonal Antibody
- 产品详情
- 实验流程
Application ![]()
| WB, E |
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Primary Accession | P23760 |
Reactivity | Human, Mouse |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 7D8G7 |
Isotype | IgG1 |
Calculated MW | 52968 Da |
Description | This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini. |
Immunogen | Purified recombinant fragment of human PAX3 (AA: 142-203) expressed in E. Coli. |
Formulation | Purified antibody in PBS with 0.05% sodium azide |
Gene ID | 5077 |
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Other Names | Paired box protein Pax-3, HuP2, PAX3, HUP2 |
Dilution | WB~~1/500 - 1/2000 E~~1/10000 |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PAX3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PAX3 |
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Synonyms | HUP2 |
Function | Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, acting synergistically with SOX10 (PubMed:21965087). |
Cellular Location | Nucleus. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
1. Cell Death Differ. 2012 Apr;19(4):616-22. 2. Biochem Biophys Res Commun. 2011 Aug 12;411(4):832-7.

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