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Mouse Monoclonal Antibody to CALB2

Purified Mouse Monoclonal Antibody

Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Western blot analysis using CALB2 mAb against human CALB2 (AA: 172-271) recombinant protein. (Expected MW is 39.2 kDa)
Western blot analysis using CALB2 mAb against HEK293 (1) and CALB2 (AA: 172-271)-hIgGFc transfected HEK293 (2) cell lysate.
Western blot analysis using CALB2 mouse mAb against HepG2 (1) and COS7 (2) cell lysate.
Flow cytometric analysis of Hela cells using CALB2 mouse mAb (green) and negative control (red).

产品详情
实验流程

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, FC, E
Primary Accession	P22676
Reactivity	Human, Monkey
Host	Mouse
Clonality	Monoclonal
Clone Names	7H1G3
Isotype	Mouse IgG1
Calculated MW	31540 Da
Description	This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering. It also functions as a modulator of neuronal excitability, and is a diagnostic marker for some human diseases, including Hirschsprung disease and some cancers. Alternative splicing results in multiple transcript variants. This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering. It also functions as a modulator of neuronal excitability, and is a diagnostic marker for some human diseases, including Hirschsprung disease and some cancers. Alternative splicing results in multiple transcript variants. ;
Immunogen	Purified recombinant fragment of human CALB2 (AA: 172-271) expressed in E. Coli.
Formulation	Purified antibody in PBS with 0.05% sodium azide
Application Note	ELISA: 1/10000; WB: 1/500 - 1/2000; FCM: 1/200 - 1/400

Additional Information
Gene ID	794
Other Names	CR; CAL2; CAB29
Dilution	WB~~1:1000 FC~~1:10~50 E~~N/A
Storage	Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions	Mouse Monoclonal Antibody to CALB2 is for research use only and not for use in diagnostic or therapeutic procedures.

Protein Information
Name	CALB2 (HGNC:1435)
Synonyms	CAB29
Function	Calcium-binding protein involved in calcium homeostasis and signal transduction. It plays a critical role in buffering intracellular calcium levels and modulating calcium-dependent signaling pathways (PubMed:2001709). Predominantly expressed in specific neuronal populations, influences synaptic plasticity and neuronal excitability, contributing to learning and memory (By similarity). During embryonic development, it facilitates neuronal differentiation and maturation (By similarity).
Cellular Location	Synapse {ECO:0000250\|UniProtKB:Q08331}. Cell projection, dendrite {ECO:0000250\|UniProtKB:Q08331}. Note=Located in dendrioles, small dendrites that makes up a brush structure found as the terminal specialization of a dendrite of a unipolar brush cell {ECO:0000250\|UniProtKB:Q08331}
Tissue Location	Brain.