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CIRBP

Purified Mouse Monoclonal Antibody

     
  • 10 - CIRBP AO2552a
    Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
  • 1 - CIRBP AO2552a
    Figure 2:Western blot analysis using CIRBP mAb against human CIRBP (AA: 1-90) recombinant protein. (Expected MW is 35.9 kDa)
  • 1 - CIRBP AO2552a
    Figure 3:Western blot analysis using CIRBP mAb against HEK293 (1) and CIRBP (AA: 1-90)-hIgGFc transfected HEK293 (2) cell lysate.
  • 2 - CIRBP AO2552a
    Figure 4:Immunohistochemical analysis of paraffin-embedded colon cancer tissues using CIRBP mouse mAb with DAB staining.
  • 2 - CIRBP AO2552a
    Figure 5:Immunohistochemical analysis of paraffin-embedded bladder cancer tissues using CIRBP mouse mAb with DAB staining.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC, ICC, E
Primary Accession Q14011
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 6E12D5
Isotype Mouse IgG1
Calculated MW 18648 Da
Immunogen Purified recombinant fragment of human CIRBP (AA: 1-90) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 1153
Other Names CIRP
Dilution WB~~ 1/500 - 1/2000
IHC~~1/200 - 1/1000
ICC~~N/A
E~~ 1/10000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCIRBP is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CIRBP
Synonyms A18HNRNP, CIRP
Function Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'- UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.
Cellular Location Nucleus, nucleoplasm. Cytoplasm Note=Translocates from the nucleus to the cytoplasm after exposure to UV radiation. Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence of TIAR proteins (By similarity).
Tissue Location Ubiquitous.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

REFERENCES

1.PLoS One. 2015 Sep 11;10(9):e0137721.2.Med Sci Monit. 2015 May 2;21:1256-60.

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