GRM5
Purified Mouse Monoclonal Antibody
- 产品详情
- 实验流程
Application ![]()
| WB, IHC, ICC, E |
---|---|
Primary Accession | P41594 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 1A11D10 |
Isotype | Mouse IgG1 |
Calculated MW | 132469 Da |
Immunogen | Purified recombinant fragment of human GRM5 (AA: extra 458-580) expressed in E. Coli. |
Formulation | Purified antibody in PBS with 0.05% sodium azide |
Gene ID | 2915 |
---|---|
Other Names | mGlu5; GPRC1E; MGLUR5; PPP1R86 |
Dilution | WB~~ 1/500 - 1/2000 IHC~~ 1/200 - 1/1000 ICC~~ 1/200 - 1/1000 E~~ 1/10000 |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | GRM5 is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GRM5 |
---|---|
Synonyms | GPRC1E, MGLUR5 |
Function | G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol- calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. |
Cellular Location | Cell membrane; Multi-pass membrane protein |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
1.Curr Alzheimer Res. 2014;11(7):694-705.2.Int J Neuropsychopharmacol. 2014 Dec;17(12):1915-22.

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