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GRM5

Purified Mouse Monoclonal Antibody

     
  • 10 - GRM5 AO2588a
    Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
  • 1 - GRM5 AO2588a
    Figure 2:Western blot analysis using GRM5 mAb against human GRM5 (AA: extra 458-580) recombinant protein. (Expected MW is 40.1 kDa)
  • 1 - GRM5 AO2588a
    Figure 3:Western blot analysis using GRM5 mAb against HEK293 (1) and GRM5 (AA: extra 458-580)-hIgGFc transfected HEK293 (2) cell lysate.
  • 8 - GRM5 AO2588a
    Figure 4:Immunofluorescence analysis of Hela cells using GRM5 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)
  • 2 - GRM5 AO2588a
    Figure 5:Immunohistochemical analysis of paraffin-embedded bladder cancer tissues using GRM5 mouse mAb with DAB staining.
  • 2 - GRM5 AO2588a
    1/200 - 1/1000
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC, ICC, E
Primary Accession P41594
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1A11D10
Isotype Mouse IgG1
Calculated MW 132469 Da
Immunogen Purified recombinant fragment of human GRM5 (AA: extra 458-580) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 2915
Other Names mGlu5; GPRC1E; MGLUR5; PPP1R86
Dilution WB~~ 1/500 - 1/2000
IHC~~ 1/200 - 1/1000
ICC~~ 1/200 - 1/1000
E~~ 1/10000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGRM5 is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GRM5
Synonyms GPRC1E, MGLUR5
Function G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol- calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity.
Cellular Location Cell membrane; Multi-pass membrane protein
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

REFERENCES

1.Curr Alzheimer Res. 2014;11(7):694-705.2.Int J Neuropsychopharmacol. 2014 Dec;17(12):1915-22.

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