CD193

Purified Mouse Monoclonal Antibody

Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Figure 2:Western blot analysis using CD193 mAb against human CD193 (AA: extra mix) recombinant protein. (Expected MW is 37.2 kDa)
Figure 3:Western blot analysis using CD193 mAb against HEK293 (1) and CD193 (AA: extra mix)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 4:Flow cytometric analysis of HL-60 cells using CD193 mouse mAb (green) and negative control (red).
Figure 5:Flow cytometric analysis of K562 cells using CD193 mouse mAb (green) and negative control (red).

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IHC, ICC, E
Primary Accession	P51677
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Clone Names	8E9H10
Isotype	Mouse IgG1
Calculated MW	41044 Da
Immunogen	Purified recombinant fragment of human CD193 (AA: extra mix) expressed in E. Coli.
Formulation	Purified antibody in PBS with 0.05% sodium azide

Additional Information
Gene ID	1232
Other Names	CKR3; CCR3; CMKBR3; CC-CKR-3
Dilution	WB~~ 1/500 - 1/2000 IHC~~1:100~500 ICC~~N/A E~~ 1/10000
Storage	Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions	CD193 is for research use only and not for use in diagnostic or therapeutic procedures.

Protein Information
Name	CCR3
Synonyms	CMKBR3
Function	Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15 (PubMed:7622448, PubMed:8642344, PubMed:8676064). Subsequently transduces a signal by increasing the intracellular calcium ions level (PubMed:8676064). In addition acts as a possible functional receptor for NARS1 (PubMed:30171954).
Cellular Location	Cell membrane; Multi-pass membrane protein
Tissue Location	In eosinophils as well as trace amounts in neutrophils and monocytes.