癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KDEL Recombinant Rabbit mAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q6UW63 |
| Other Accession | Q6UW63 |
| Reactivity | Rat, Human, Mouse |
| Host | Rabbit |
| Clonality | Recombinant |
| Calculated MW | 58043 Da |
| Physical State | Liquid |
| Immunogen | A synthesized peptide derived from KDEL |
| Epitope Specificity | KDEL |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| SIMILARITY | Belongs to the KDELC family. Contains 1 filamin repeat. |
| SUBUNIT | Interacts with DNAJC1 (via J domain). Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Part a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Interacts with TMEM132A and TRIM21. May form a complex with ERLEC1, OS9, SEL1L and SYVN1. |
| Post-translational modifications | N-glycosylated. |
| DISEASE | Note=Autoantigen in rheumatoid arthritis. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum. |
| Gene ID | 79070 |
|---|---|
| Other Names | PLGT2_HUMAN; POGLUT2; Endoplasmic reticulum resident protein 58 (ER protein 58 | ERp58); KDEL motif-containing protein 1; Protein O-xylosyltransferase POGLUT2; 2.4.1.-; EP58; KDELC1; PLGT2_MOUSE; B5DFA5_RAT; protein O-glucosyltransferase 2; KDEL (Lys-Asp-Glu-Leu) containing 1; KDEL motif containing 1 |
| Dilution | WB=1:500-2000,ICC/IF=1:50-200,Flow-Cyt=1:50-100 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | POGLUT2 {ECO:0000303|PubMed:30127001, ECO:0000312|HGNC:HGNC:19350} |
|---|---|
| Function | Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C (PubMed:30127001). Can also catalyze the transfer of xylose from UDP-xylose but less efficiently (PubMed:30127001). Specifically targets extracellular EGF repeats of proteins such as NOTCH1, NOTCH3, FBN1, FBN2 and LTBP1 (PubMed:30127001, PubMed:34411563). May regulate the transport of NOTCH1 and NOTCH3 to the plasma membrane and thereby the Notch signaling pathway (PubMed:30127001). |
| Cellular Location | Endoplasmic reticulum lumen {ECO:0000255|PROSITE- ProRule:PRU10138} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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