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USP14 Recombinant Rabbit mAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | O95147 |
| Other Accession | O95147 |
| Host | Rabbit |
| Clonality | Recombinant |
| Calculated MW | 22255 Da |
| Physical State | Liquid |
| Immunogen | A synthesized peptide derived from human USP14 |
| Epitope Specificity | 350-494/494 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| SIMILARITY | Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 tyrosine-protein phosphatase domain. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Ubiquitin-Specific Protease 14, which is also known as the 60 kDa subunit of tRNA-guanine transglycosylase (USP14/TGT60 kDa). USP14 is recruited to the proteasome through its reversible association with the PSMD2 (S2/hRPN1) subunit of the 19S regulatory particle. Whereas PSMD14 appears to promote substrate degradation, USP14 is thought to antagonize substrate degradation. |
| Gene ID | 11072 |
|---|---|
| Other Names | MKP-L; MKP6; DUS14_HUMAN; DUSP14; MKP-1-like protein tyrosine phosphatase (MKP-L); Mitogen-activated protein kinase phosphatase 6 (MAP kinase phosphatase 6 | MKP-6); 3.1.3.16; 3.1.3.48; ubiquitin specific peptidase 14; ubiquitin specific protease 14 (tRNA-guanine transglycosylase); ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) |
| Dilution | WB=1:1000-2000,ICC/IF=1:100-200,Flow-Cyt=1:100-200 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | DUSP14 |
|---|---|
| Synonyms | MKP6 |
| Function | Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases. Plays a negative role in TCR signaling by dephosphorylating MAP3K7 adapter TAB1 leading to its inactivation (PubMed:24403530). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP100012
