癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SLIT2 Recombinant Rabbit mAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, IP |
|---|---|
| Primary Accession | O94813 |
| Other Accession | O94813 |
| Reactivity | Rat, Human, Mouse |
| Host | Rabbit |
| Clonality | Recombinant |
| Calculated MW | 169870 Da |
| Physical State | Liquid |
| Immunogen | A synthesized peptide derived from human Slit 2 |
| Epitope Specificity | 1400-1500/1529 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| SIMILARITY | Contains 1 CTCK (C-terminal cystine knot-like) domain. Contains 7 EGF-like domains. Contains 1 laminin G-like domain. Contains 20 LRR (leucine-rich) repeats. Contains 4 LRRCT domains. Contains 4 LRRNT domains. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. |
| Gene ID | 9353 |
|---|---|
| Other Names | SLIL3; Slit-2; Drad-1; E030015M03Rik; E130320P19Rik; b2b1200.1Clo; mKIAA4141; SLIT2_HUMAN; SLIT2; SLIT2_MOUSE; SLIT2_RAT; slit guidance ligand 2; slit (Drosophila) homolog 2; slit homolog 2 (Drosophila) |
| Dilution | WB=1:500-2000,IHC-P=1:200-800,IHC-F=1:200-800,IP=1:20-50,IF=1:200-800 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SLIT2 |
|---|---|
| Synonyms | SLIL3 |
| Function | Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal cord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. May be implicated in spinal cord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration. |
| Cellular Location | Secreted. Note=The C-terminal cleavage protein is more diffusible than the larger N- terminal protein that is more tightly cell associated |
| Tissue Location | Fetal lung and kidney, and adult spinal cord. Weak expression in adult adrenal gland, thyroid, trachea and other tissues examined. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,400.00
Cat# AP100018
