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XDH Recombinant Rabbit mAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P47989 |
| Other Accession | P47989 |
| Host | Rabbit |
| Clonality | Recombinant |
| Calculated MW | 146424 Da |
| Physical State | Liquid |
| Immunogen | A synthesized peptide derived from human Xanthine oxidase |
| Epitope Specificity | 202-300 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| SIMILARITY | Belongs to the xanthine dehydrogenase family.Contains 1 2Fe-2S ferredoxin-type domain.Contains 1 FAD-binding PCMH-type domain. |
| SUBUNIT | Homodimer. Interacts with BTN1A1. |
| Post-translational modifications | Subject to partial proteolysis; this alters the enzyme from the dehydrogenase form (D) to the oxidase form (O) (By similarity).Contains sulfhydryl groups that are easily oxidized (in vitro); this alters the enzyme from the dehydrogenase form (D) to the oxidase form (O) (By similarity). |
| DISEASE | Defects in XDH are the cause of xanthinuria type 1 (XU1) [MIM:278300]. Xanthinuria is characterized by excretion of very large amounts of xanthine in the urine and a tendency to form xanthine stones. Uric acid is strikingly diminished in serum and urine. XU1 is due to isolated xanthine dehydrogenase. XU1 patients can metabolize allopurinol. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro). |
| Gene ID | 7498 |
|---|---|
| Other Names | XAN1; XDH/XO; XO; XOR; Xox-1; Xox1; XDH_HUMAN; XDH; XDHA; XDH_MOUSE; XDH_RAT; xanthine dehydrogenase; xanthene dehydrogenase; xanthine dehydrogenase/oxidase; xanthine oxidase; xanthine oxidoreductase |
| Dilution | WB=1:500-2000,IHC-P=1:50-200,IHC-F=1:50-200,IF=1:50-200,Flow-Cyt=1:50-100 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | XDH |
|---|---|
| Synonyms | XDHA |
| Function | Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro). |
| Cellular Location | Cytoplasm. Peroxisome. Secreted |
| Tissue Location | Detected in milk (at protein level). {ECO:0000269|Ref.12} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP100025
