癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SCARB2 Recombinant Rabbit mAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, IP |
|---|---|
| Primary Accession | Q14108 |
| Other Accession | Q14108 |
| Reactivity | Rat, Human, Mouse |
| Host | Rabbit |
| Clonality | Recombinant |
| Calculated MW | 54290 Da |
| Physical State | Liquid |
| Immunogen | A synthesized peptide derived from human SCARB2 |
| Epitope Specificity | 61-100/478 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| SIMILARITY | Belongs to the CD36 family. |
| SUBUNIT | Interacts with GBA (via the coiled-coil domain). |
| DISEASE | Defects in SCARB2 are the cause of progressive myoclonic epilepsy type 4 with or without renal failure (EPM4) [MIM:254900]. An autosomal recessive progressive myoclonic epilepsy associated with renal failure in some cases. Cognitive function is preserved. Myoclonus is a brief, involuntary twitching of a muscle or a group of muscles. Cognitive function is preserved. Note=Genetic variants in SCARB2 can act as modifier of the phenotypic expression and severity of Gaucher disease. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Acts as a lysosomal receptor for glucosylceramidase (GBA1) targeting. |
| Gene ID | 950 |
|---|---|
| Other Names | AMRF; CD36L2; EPM4; HLGP85; LGP85; LIMP-2; LIMPII; SR-BII; 9330185J12Rik; LIMP II; MLGP85; SCRB2_HUMAN; SCARB2; 85 kDa lysosomal membrane sialoglycoprotein (LGP85); CD36 antigen-like 2; Lysosome membrane protein II (LIMP II); Scavenger receptor class B member 2; LIMP2; SCRB2_MOUSE; SCRB2_RAT; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II); lysosome membrane protein 2; lysosomal integral membrane protein II |
| Dilution | WB=1:500-2000,IHC-P=1:200-500,IHC-F=1:200-500,IP=1:20-50,Flow-Cyt=1:50-100,IF=1:200-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SCARB2 |
|---|---|
| Synonyms | CD36L2, LIMP2, LIMPII |
| Function | Acts as a lysosomal receptor for glucosylceramidase (GBA1) targeting. |
| Cellular Location | Lysosome membrane; Multi-pass membrane protein |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,400.00
Cat# AP100031
