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CNTNAP2 Recombinant Rabbit mAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9UHC6 |
| Other Accession | Q9UHC6 |
| Host | Rabbit |
| Clonality | Recombinant |
| Calculated MW | 148167 Da |
| Physical State | Liquid |
| Immunogen | A synthesized peptide derived from human CNTNAP2 |
| Epitope Specificity | 1300-1331/1331 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| SIMILARITY | Belongs to the neurexin family.Contains 2 EGF-like domains.Contains 1 F5/8 type C domain.Contains 1 fibrinogen C-terminal domain.Contains 4 laminin G-like domains. |
| SUBUNIT | Associates with KCNA2. |
| DISEASE | Defects in CNTNAP2 are the cause of cortical dysplasia-focal epilepsy syndrome (CDFES) [MIM:610042]. Affected individuals manifest cortical dysplasia, focal epilepsy, relative macrocephaly, and diminished deep-tendon reflexes. Intractable focal seizures begin in early childhood, after which language regression, hyperactivity, impulsive and aggressive behavior, and mental retardation develop. Genetic variations in CNTNAP2 influences susceptibility to autism type 15 (AUTS15) [MIM:612100]. Autism is a neurodevelopmental disorder characterized by disturbance in language, perception and socialization. The disorder is classically defined by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, stereotypical, and ritualized patterns of interests and behavior. Note=A chromosomal aberration involving CNTNAP2 is found in a patient with autism spectrum disorder. Paracentric inversion 46,XY,inv(7)(q11.22;q35). The inversion breakpoints disrupt the genes AUTS2 and CNTNAP2. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Required for gap junction formation (Probable). Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the juxtaparanodal region of the axo-glial junction. |
| Gene ID | 26047 |
|---|---|
| Other Names | AUTS15; CASPR2; CDFE; NRXN4; PTHSL1; 5430425M22Rik; mKIAA0868; CNTP2_HUMAN; CNTNAP2; Cell recognition molecule Caspr2; KIAA0868; CNTP2_MOUSE; contactin associated protein 2; contactin associated protein like 2 |
| Dilution | WB=1:500-2000,IHC-P=1:50-200,IHC-F=1:50-200,IF=1:50-200 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CNTNAP2 |
|---|---|
| Synonyms | CASPR2 {ECO:0000303|PubMed:10624965}, KI |
| Function | Required for gap junction formation (Probable). Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the juxtaparanodal region of the axo-glial junction. |
| Cellular Location | Membrane {ECO:0000250|UniProtKB:Q9CPW0}; Single- pass type I membrane protein. Cell projection, axon {ECO:0000250|UniProtKB:Q9CPW0}. Cell junction, paranodal septate junction {ECO:0000250|UniProtKB:Q9CPW0}. Note=Expressed in the juxtaparadonal region. {ECO:0000250|UniProtKB:Q9CPW0} |
| Tissue Location | Predominantly expressed in nervous system. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP100039
