癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
OTX1/2 Recombinant Rabbit mAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, IP, CHIP |
|---|---|
| Primary Accession | P32242 |
| Other Accession | P32242 |
| Host | Rabbit |
| Clonality | Recombinant |
| Calculated MW | 37327 Da |
| Physical State | Liquid |
| Immunogen | A synthesized peptide derived from human OTX1 |
| Epitope Specificity | 20-70 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| SIMILARITY | Belongs to the paired homeobox family. Bicoid subfamily. Contains 1 homeobox DNA-binding domain. |
| DISEASE | Defects in OTX2 are the cause of microphthalmia syndromic type 5 (MCOPS5) [MIM:610125]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Up to 80% of cases of microphthalia occur in association with syndromes that include non-ocular abnormalities. MCOPS5 patients manifest unilateral or bilateral microphthalmia/clinical anophthalmia and variable additional features including coloboma, microcornea, cataract, retinal dystrophy, hypoplasia or agenesis of the optic nerve, agenesis of the corpus callosum, developmental delay, joint laxity, hypotonia, and seizures. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'. |
| Gene ID | 5013 |
|---|---|
| Other Names | CPHD6; MCOPS5; A730044F23Rik; jv; id:ibd2915; otx2; zOtx2; zgc:136535; zotx-2; OTX1_HUMAN; OTX1; Orthodenticle homolog 1; OTX2_HUMAN; Orthodenticle homolog 2; OTX1_MOUSE; Otx-1; OTX2_MOUSE; Otx-2; OTX2_DANRE; orthodenticle homeobox 1; orthodenticle (Drosophila) homolog 1; orthodenticle homolog 1 (Drosophila); Homeobox protein OTX1 |
| Dilution | WB=1:500-2000,IHC-P=1:50-200,IHC-F=1:50-200,IP=1:20-50,ChIP=1:20-50,IF=1:50-200 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | OTX1 |
|---|---|
| Function | Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC- 3'. |
| Cellular Location | Nucleus. |
| Tissue Location | Expressed in brain. Detected in the anterior part of the neural fetal retina (at protein level) |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP100060
