癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Cytokeratin 6 Recombinant Rabbit mAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P48668 |
| Other Accession | P48668 |
| Host | Rabbit |
| Clonality | Recombinant |
| Calculated MW | 60025 Da |
| Physical State | Liquid |
| Immunogen | A synthesized peptide derived from human Cytokeratin 6 |
| Epitope Specificity | 500-564 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| SIMILARITY | Belongs to the intermediate filament family. |
| SUBUNIT | Heterodimer of a type I and a type II keratin. KRT6 isomers associate with KRT16 and/or KRT17. Interacts with TCHP. |
| DISEASE | Defects in KRT6A are a cause of pachyonychia congenital type 1 (PC1) [MIM:167200]; also known as Jadassohn-Lewandowsky syndrome. PC1 is an autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma, follicular hyperkeratosis, and oral leukokeratosis. Hyperhidrosis of the hands and feet is usually present. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair. |
| Gene ID | 286887 |
|---|---|
| Other Names | K6E; KRT6E; PPKNEFD; 2310016L08Rik; CK-6A; K6A; K6[a]; Krt2-6a; Krt2-6c; MK6a; mK6[a]; K2C6C_HUMAN; KRT6C; Cytokeratin-6C (CK-6C); Cytokeratin-6E (CK-6E); Keratin K6h; Keratin-6C (K6C); Type-II keratin Kb12; K2C6A_MOUSE; Krt6a; Cytokeratin-6A (CK-6A); Keratin-6-alpha (mK6-alpha); Keratin-6A (K6A); Ker2; Krt2-6; Krt6; keratin 6C; keratin 6E; keratin 6C, type II |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,Flow-Cyt=1:50-100 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | KRT6C (HGNC:20406) |
|---|---|
| Synonyms | KRT6E |
| Function | Structural component of intermediate filaments in epithelial keratinocytes. Forms heteropolymers with the type I keratins, likely including KRT16 and KRT17, assembling keratin intermediate filament networks that contribute to the structural framework and mechanical resilience of stratified epithelia, particularly in palmoplantar epidermis. |
| Tissue Location | Constitutively expressed in distinct types of epithelia such as those in oral mucosa, esophagus, papillae of tongue and hair follicle outer root sheath. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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