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SEC61B | SEC61 beta Mouse mAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IF, IP, E |
|---|---|
| Primary Accession | P60468 |
| Other Accession | P60468 |
| Predicted | Rat, Human, Mouse |
| Host | Mouse |
| Clonality | Monoclonal |
| Calculated MW | 9974 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human SEC61 beta |
| Isotype | IgG2a, κ |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the SEC61-beta family. |
| SUBUNIT | Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma. Part of a complex composed of SEC61, SEC62 and SEC63. Interacts with SEC62. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript. [provided by RefSeq, Jul 2008] |
| Gene ID | 10952 |
|---|---|
| Other Names | 1190006C12Rik; SC61B_CANLF; SEC61B; SC61B_HUMAN; SC61B_MOUSE; SEC61 translocon subunit beta; Sec61 beta subunit |
| Dilution | WB=1:100-1000,IHC-P=1:100-500,IF=1:100-500,IP=1:20-100,ELISA=1:30-3000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SEC61B {ECO:0000303|PubMed:28375157, ECO:0000312|HGNC:HGNC:16993} |
|---|---|
| Function | Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (PubMed:12475939). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (PubMed:12475939). The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex (PubMed:32820719, PubMed:36261522). The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (PubMed:19121997). |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass membrane protein |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP100074
