癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TUSC5 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q8IXB3 |
| Other Accession | Q8IXB3 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 19254 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human TUSC5 |
| Epitope Specificity | 101-177/177 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the CD225/Dispanin family. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | TUSC5 may be involved in fat metabolism. It is expressed at high levels in heart, mammary gland, adrenal gland, stomach, smooth muscle and skeletal muscle and at lower levels in brain and lung. TUSC5 is strongly down regulated in lung cancer tissues, due to hypermethylation of the corresponding locus. |
| Gene ID | 286753 |
|---|---|
| Other Names | BEC-1; DSPB1; IFITMD3; LOST1; TUSC5; TARG1_HUMAN; TRARG1; Dispanin subfamily B member 1 (DSPB1); Interferon-induced transmembrane domain-containing protein D3; Protein located at seventeen-p-thirteen point three 1; Tumor suppressor candidate 5; trafficking regulator of GLUT4 (SLC2A4) 1 (gene/pseudogene); trafficking regulator of GLUT4 (SLC2A4) 1; located at seventeen p thirteen point three 1; interferon induced transmembrane protein domain containing 3; dispanin subfamily B member 1; brain endothelial cell derived gene-1 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TRARG1 (HGNC:29592) |
|---|---|
| Function | Regulates insulin-mediated adipose tissue glucose uptake and transport by modulation of SLC2A4 recycling. Not required for SLC2A4 membrane fusion upon an initial stimulus, but rather is necessary for proper protein recycling during prolonged insulin stimulation. |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q8C838}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q8C838} Endomembrane system {ECO:0000250|UniProtKB:Q8C838}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q8C838}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8C838}. Note=Shifts from low-density microsome vesicles to the cell membrane upon insulin stimulation {ECO:0000250|UniProtKB:Q8C838} |
| Tissue Location | Expressed at high levels in heart, mammary gland, adrenal gland, stomach, smooth muscle and skeletal muscle, and at lower levels in brain and lung. Strongly down-regulated in lung cancer tissues, due to hypermethylation of the corresponding locus (PubMed:12660825). Expressed in adipose tissue (PubMed:26629404) |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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Cat# AP100133
