癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CRIPTO Mouse mAb
- 产品详情
- 实验流程
Application 
| WB, E |
|---|---|
| Primary Accession | P13385 |
| Other Accession | P13385 |
| Host | Mouse |
| Clonality | Monoclonal |
| Calculated MW | 21169 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human TDGF1 |
| Epitope Specificity | 101-188/188 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 EGF-like domain. |
| SUBUNIT | Interacts with the activin type-1 receptor ACVR1B. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]. |
| Gene ID | 6997 |
|---|---|
| Other Names | TDGF1; CR; CR-1; CRGF; CR1; TDGF1_HUMAN; CRIPTO; Cripto, EGF-CFC family member; Cripto-1 growth factor (CRGF); Epidermal growth factor-like cripto protein CR1; Teratocarcinoma-derived growth factor 1; CRIPTO-1; TDGF1_MOUSE; Cripto growth factor; Epidermal growth factor-like Cripto protein; |
| Dilution | WB=1:500-2000,ICC/IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CRIPTO {ECO:0000303|PubMed:2792079, ECO:0000312|HGNC:HGNC:11701} |
|---|---|
| Function | GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated CRIPTO acts as a Nodal coreceptor in cis. Shedding of CRIPTO by TMEM8A modulates Nodal signaling by allowing soluble CRIPTO to act as a Nodal coreceptor on other cells (PubMed:27881714). Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm (PubMed:11909953). |
| Cellular Location | Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Released from the cell membrane by GPI cleavage. |
| Tissue Location | Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP100138
